abstract：:Lysosomes play a critical role in maintenance of the integrity of neuronal function, and mutations in genes that contribute to lysosome formation, transport, and activity are associated with neurodegenerative disorders. Recently, the multisubunit complex, BLOC-one-related complex (BORC), has been shown to be involved ...

journal_title：Cell reports

authors： Snouwaert JN,Church RJ,Jania L,Nguyen M,Wheeler ML,Saintsing A,Mieczkowski P,Manuel de Villena FP,Armao D,Moy SS,Lorenzo DN,Koller BH

更新日期：2018-07-31 00:00:00

abstract：:While meta-analysis has demonstrated increased statistical power and more robust estimations in studies, the application of this commonly accepted methodology to cytometry data has been challenging. Different cytometry studies often involve diverse sets of markers. Moreover, the detected values of the same marker are ...

journal_title：Cell reports

authors： Hu Z,Jujjavarapu C,Hughey JJ,Andorf S,Lee HC,Gherardini PF,Spitzer MH,Thomas CG,Campbell J,Dunn P,Wiser J,Kidd BA,Dudley JT,Nolan GP,Bhattacharya S,Butte AJ

更新日期：2018-07-31 00:00:00

abstract：:CRISPR-Cas13a enzymes are RNA-guided, RNA-activated RNases. Their properties have been exploited as powerful tools for RNA detection, RNA imaging, and RNA regulation. However, the relationship between target RNA binding and HEPN (higher eukaryotes and prokaryotes nucleotide binding) domain nuclease activation is poorl...

journal_title：Cell reports

authors： Tambe A,East-Seletsky A,Knott GJ,Doudna JA,O'Connell MR

更新日期：2018-07-24 00:00:00

abstract：:Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-labeled CD11c+ and CD11cneg T-bet+ IgM memory cells after their tra...

journal_title：Cell reports

authors： Kenderes KJ,Levack RC,Papillion AM,Cabrera-Martinez B,Dishaw LM,Winslow GM

更新日期：2018-07-24 00:00:00

abstract：:Mutations in BLM helicase predispose Bloom syndrome (BS) patients to a wide spectrum of cancers. We demonstrate that MIB1-ubiquitylated BLM in G1 phase functions as an adaptor protein by enhancing the binding of transcription factor c-Jun and its E3 ligase, Fbw7α. BLM enhances the K48/K63-linked ubiquitylation on c-Ju...

journal_title：Cell reports

authors： Priyadarshini R,Hussain M,Attri P,Kaur E,Tripathi V,Priya S,Dhapola P,Saha D,Madhavan V,Chowdhury S,Sengupta S

更新日期：2018-07-24 00:00:00

abstract：:Wiskott-Aldrich syndrome protein (WASp) is a main cytoskeletal regulator in B cells. WASp-interacting protein (WIP) binds to and stabilizes WASp but also interacts with actin. Using mice with a mutated actin binding domain of WIP (WIPΔABD), we here investigated the role of WIP binding to actin during B cell activation...

journal_title：Cell reports

authors： Keppler SJ,Burbage M,Gasparrini F,Hartjes L,Aggarwal S,Massaad MJ,Geha RS,Bruckbauer A,Batista FD

更新日期：2018-07-17 00:00:00

abstract：:The centromere binding factor 3 (CBF3) complex binds the third centromere DNA element in organisms with point centromeres, such as S. cerevisiae. It is an essential complex for assembly of the kinetochore in these organisms, as it facilitates genetic centromere specification and allows association of all other kinetoc...

journal_title：Cell reports

authors： Zhang W,Lukoyanova N,Miah S,Lucas J,Vaughan CK

更新日期：2018-07-17 00:00:00

abstract：:In the presynaptic terminal, the magnitude and location of Ca2+ entry through voltage-gated Ca2+ channels (VGCCs) regulate the efficacy of neurotransmitter release. However, how presynaptic active zone proteins control mammalian VGCC levels and organization is unclear. To address this, we deleted the CAST/ELKS protein...

journal_title：Cell reports

authors： Dong W,Radulovic T,Goral RO,Thomas C,Suarez Montesinos M,Guerrero-Given D,Hagiwara A,Putzke T,Hida Y,Abe M,Sakimura K,Kamasawa N,Ohtsuka T,Young SM Jr

更新日期：2018-07-10 00:00:00

abstract：:Activation of phosphoinositide 3-kinase (PI3K) signaling plays a central role in regulating proliferation and survival of B cells. Here, we tested the hypothesis that B cell receptor (BCR)-mediated activation of PI3K induces the terminal differentiation factor Blimp-1 that interferes with proliferation and survival, t...

journal_title：Cell reports

authors： Setz CS,Hug E,Khadour A,Abdelrasoul H,Bilal M,Hobeika E,Jumaa H

更新日期：2018-07-10 00:00:00

abstract：:A systematic cataloging of genes affected by genomic rearrangement, using multiple patient cohorts and cancer types, can provide insight into cancer-relevant alterations outside of exomes. By integrative analysis of whole-genome sequencing (predominantly low pass) and gene expression data from 1,448 cancers involving ...

journal_title：Cell reports

authors： Zhang Y,Yang L,Kucherlapati M,Chen F,Hadjipanayis A,Pantazi A,Bristow CA,Lee EA,Mahadeshwar HS,Tang J,Zhang J,Seth S,Lee S,Ren X,Song X,Sun H,Seidman J,Luquette LJ,Xi R,Chin L,Protopopov A,Li W,Park PJ,Kuche

更新日期：2018-07-10 00:00:00

abstract：:Maintenance of skeletal muscle mass requires a dynamic balance between protein synthesis and tightly controlled protein degradation by the calpain, autophagy-lysosome, and ubiquitin-proteasome systems (proteostasis). Several sensing and gene-regulatory mechanisms act together to maintain this balance in response to ch...

journal_title：Cell reports

authors： Singh RK,Kolonin AM,Fiorotto ML,Cooper TA

更新日期：2018-07-03 00:00:00

abstract：:Obesity is associated with colon cancer pathogenesis, but the underlying mechanism is actively debated. Here, we confirm that diet-induced obesity promotes tumor growth in two murine colon cancer models and show that this effect is reversed by an orally administered controlled-release mitochondrial protonophore (CRMP)...

journal_title：Cell reports

authors： Wang Y,Nasiri AR,Damsky WE,Perry CJ,Zhang XM,Rabin-Court A,Pollak MN,Shulman GI,Perry RJ

更新日期：2018-07-03 00:00:00

abstract：:The intestinal tract is constantly exposed to various stimuli. Group 3 innate lymphoid cells (ILC3s) reside in lymphoid organs and in the intestinal tract and are required for immunity to enteric bacterial infection. However, the mechanisms that regulate the ILC3s in vivo remain incompletely defined. Here, we show tha...

journal_title：Cell reports

authors： Chu C,Moriyama S,Li Z,Zhou L,Flamar AL,Klose CSN,Moeller JB,Putzel GG,Withers DR,Sonnenberg GF,Artis D

更新日期：2018-06-26 00:00:00

abstract：:Fear extinction is a component of cognitive flexibility that is relevant for important psychiatric diseases, but its molecular mechanism is still largely elusive. We established mice lacking the kinesin-4 motor KIF21B as a model for fear extinction defects. Postsynaptic NMDAR-dependent long-term depression (LTD) is sp...

journal_title：Cell reports

authors： Morikawa M,Tanaka Y,Cho HS,Yoshihara M,Hirokawa N

更新日期：2018-06-26 00:00:00

abstract：:Pancreatitis is an inflammatory disease of the exocrine pancreas and ranks among the most common gastrointestinal disorders. Inflamed tissues frequently experience conditions of insufficient oxygen availability, or hypoxia. Here, we demonstrate that hypoxia and consequent stabilization of the hypoxia-inducible factor ...

journal_title：Cell reports

authors： Lee KE,Spata M,Maduka R,Vonderheide RH,Simon MC

更新日期：2018-06-19 00:00:00

abstract：:Mitophagy plays an important role in mitochondrial quality control. In yeast, phosphorylation of the mitophagy receptor Atg32 by casein kinase 2 (CK2) upon induction of mitophagy is a prerequisite for interaction of Atg32 with Atg11 (an adaptor protein for selective autophagy) and following delivery of mitochondria to...

journal_title：Cell reports

authors： Furukawa K,Fukuda T,Yamashita SI,Saigusa T,Kurihara Y,Yoshida Y,Kirisako H,Nakatogawa H,Kanki T

更新日期：2018-06-19 00:00:00

abstract：:Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast-acting antidepressant properties of the dissociative anesthetic ketamine....

journal_title：Cell reports

authors： Ly C,Greb AC,Cameron LP,Wong JM,Barragan EV,Wilson PC,Burbach KF,Soltanzadeh Zarandi S,Sood A,Paddy MR,Duim WC,Dennis MY,McAllister AK,Ori-McKenney KM,Gray JA,Olson DE

更新日期：2018-06-12 00:00:00

abstract：:Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand in conditions of low glucose supply. Many tissues oxidize fat as an alternate energy substrate. Here, we show th...

journal_title：Cell reports

authors： Briant LJB,Dodd MS,Chibalina MV,Rorsman NJG,Johnson PRV,Carmeliet P,Rorsman P,Knudsen JG

更新日期：2018-06-12 00:00:00

abstract：:Spinal cord longitudinal axons comprise some of the longest axons in our body. However, mechanisms that drive this extra long-distance axonal growth are largely unclear. We found that ascending axons of rapidly adapting (RA) mechanoreceptors closely abut a previously undescribed population of roof plate-derived radial...

journal_title：Cell reports

authors： Kridsada K,Niu J,Haldipur P,Wang Z,Ding L,Li JJ,Lindgren AG,Herrera E,Thomas GM,Chizhikov VV,Millen KJ,Luo W

更新日期：2018-06-05 00:00:00

abstract：:We assessed the subsistence-related variation of the human gut microbiome at a fine resolution for two of the main dimensions of microbiome variation, age and geography. For this, we investigated the fecal microbiome and metabolome in rural Bassa and urbanized individuals from Nigeria, including infants, and compared ...

journal_title：Cell reports

authors： Ayeni FA,Biagi E,Rampelli S,Fiori J,Soverini M,Audu HJ,Cristino S,Caporali L,Schnorr SL,Carelli V,Brigidi P,Candela M,Turroni S

更新日期：2018-06-05 00:00:00

abstract：:The bacterial pathogen Listeria monocytogenes (Lm) capitalizes on natural killer (NK) cell production of regulatory interleukin (IL)-10 to establish severe systemic infections. Here, we identify regulators of this IL-10 secretion. We show that IL-18 signals to NK cells license their ability to produce IL-10. IL-18 act...

journal_title：Cell reports

authors： Clark SE,Schmidt RL,McDermott DS,Lenz LL

更新日期：2018-05-29 00:00:00

abstract：:Autism spectrum disorders (ASDs) are associated with mutations affecting synaptic components, including GluN2B-NMDA receptors (NMDARs) and neurobeachin (NBEA). NBEA participates in biosynthetic pathways to regulate synapse receptor targeting, synaptic function, cognition, and social behavior. However, the role of NBEA...

journal_title：Cell reports

authors： Gromova KV,Muhia M,Rothammer N,Gee CE,Thies E,Schaefer I,Kress S,Kilimann MW,Shevchuk O,Oertner TG,Kneussel M

更新日期：2018-05-29 00:00:00

abstract：:Impulses generated by a multicellular, bioelectric signaling center termed the sinoatrial node (SAN) stimulate the rhythmic contraction of the heart. The SAN consists of a network of electrochemically oscillating pacemaker cells encased in a heterogeneous connective tissue microenvironment. Although the cellular compo...

journal_title：Cell reports

authors： Bressan M,Henley T,Louie JD,Liu G,Christodoulou D,Bai X,Taylor J,Seidman CE,Seidman JG,Mikawa T

更新日期：2018-05-22 00:00:00

abstract：:How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical Bisphenol A in C. elegans. We show that Bisphenol A (BPA) exposure causes ...

journal_title：Cell reports

authors： Camacho J,Truong L,Kurt Z,Chen YW,Morselli M,Gutierrez G,Pellegrini M,Yang X,Allard P

更新日期：2018-05-22 00:00:00

abstract：:Despite the comprehensive knowledge on odor coding, our understanding of the relationship between sensory input and behavioral output in Drosophila remains weak. Here, we measure the behavioral responses generated by larval and adult flies in response to 34 fruit odors and find that larval preference for fruit odors d...

journal_title：Cell reports

authors： Dweck HKM,Ebrahim SAM,Retzke T,Grabe V,Weißflog J,Svatoš A,Hansson BS,Knaden M

更新日期：2018-05-22 00:00:00

abstract：:Primary afferents transduce environmental stimuli into electrical activity that is transmitted centrally to be decoded into corresponding sensations. However, it remains unknown how afferent populations encode different somatosensory inputs. To address this, we performed two-photon Ca2+ imaging from thousands of dorsa...

journal_title：Cell reports

authors： Wang F,Bélanger E,Côté SL,Desrosiers P,Prescott SA,Côté DC,De Koninck Y

更新日期：2018-05-15 00:00:00

abstract：:Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical outcomes have been associated with decreased expansion and persistence of adoptively transferred CAR T cells, antigen-negative relapses, a...

journal_title：Cell reports

authors： Avanzi MP,Yeku O,Li X,Wijewarnasuriya DP,van Leeuwen DG,Cheung K,Park H,Purdon TJ,Daniyan AF,Spitzer MH,Brentjens RJ

更新日期：2018-05-15 00:00:00

abstract：:Clinical transplantation of tissue fragments, including islets, faces a critical challenge because of a lack of effective strategies that ensure efficient engraftment through the timely integration of vascular networks. We recently developed a complex organoid engineering method by "self-condensation" culture based on...

journal_title：Cell reports

authors： Takahashi Y,Sekine K,Kin T,Takebe T,Taniguchi H

更新日期：2018-05-08 00:00:00

abstract：:Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors. These processes govern mitochondria subcellular distribution, whose defects are emphasized in neurons because of their polarized structure. We have studie...

journal_title：Cell reports

authors： Trevisan T,Pendin D,Montagna A,Bova S,Ghelli AM,Daga A

更新日期：2018-05-08 00:00:00

abstract：:Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells (NFAT) signaling pathway is central to endothelial cell angiogenic responses, and it is activated by ...

journal_title：Cell reports

authors： Rozen EJ,Roewenstrunk J,Barallobre MJ,Di Vona C,Jung C,Figueiredo AF,Luna J,Fillat C,Arbonés ML,Graupera M,Valverde MA,de la Luna S

更新日期：2018-05-08 00:00:00

abstract：:The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeostasis during adaptive stress responses. However, the precise control mechanism of muscle mitochondrial quality and its physiological impacts remain unclear. Here, we demonstrate that FUNDC1, a mediator of mitophagy, plays a cri...

journal_title：Cell reports

authors： Fu T,Xu Z,Liu L,Guo Q,Wu H,Liang X,Zhou D,Xiao L,Liu L,Liu Y,Zhu MS,Chen Q,Gan Z

更新日期：2018-05-01 00:00:00

abstract：:Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can lead to aneuploidy and tumor formation. Tumor suppressor mechanisms limiting the oncogenic potential of these cells have been described. However, the universal applicability of these tumor-suppressive barriers remains contro...

journal_title：Cell reports

authors： Gerlach SU,Eichenlaub T,Herranz H

更新日期：2018-05-01 00:00:00

abstract：:Sirtuin 2 is a nicotinamide-adenine-dinucleotide-dependent deacetylase that regulates cell processes such as carcinogenesis, cell cycle, DNA damage, and infection. Subcellular localization of SIRT2 is crucial for its function but is poorly understood. Infection with the bacterial pathogen Listeria monocytogenes, which...

journal_title：Cell reports

authors： Pereira JM,Chevalier C,Chaze T,Gianetto Q,Impens F,Matondo M,Cossart P,Hamon MA

更新日期：2018-04-24 00:00:00

abstract：:In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during "open" mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (MI) are "closed," during which the NE is maintained. Intriguingly, during the second meiotic division (MII), the NE is also main...

journal_title：Cell reports

authors： Flor-Parra I,Iglesias-Romero AB,Salas-Pino S,Lucena R,Jimenez J,Daga RR

更新日期：2018-04-24 00:00:00

abstract：:Cytoplasmic long non-coding RNAs have been shown to act at many different levels to control post-transcriptional gene expression, although their role in translational control is poorly understood. Here, we show that lnc-31, a non-coding RNA required for myoblast proliferation, promotes ROCK1 protein synthesis by stabi...

journal_title：Cell reports

authors： Dimartino D,Colantoni A,Ballarino M,Martone J,Mariani D,Danner J,Bruckmann A,Meister G,Morlando M,Bozzoni I

更新日期：2018-04-17 00:00:00

abstract：:Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the s...

journal_title：Cell reports

authors： Munanairi A,Liu XY,Barry DM,Yang Q,Yin JB,Jin H,Li H,Meng QT,Peng JH,Wu ZY,Yin J,Zhou XY,Wan L,Mo P,Kim S,Huo FQ,Jeffry J,Li YQ,Bardoni R,Bruchas MR,Chen ZF

更新日期：2018-04-17 00:00:00

abstract：:Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is enforced is not known. Here, we define key elements requisite for the respons...

journal_title：Cell reports

authors： Wei T,Najmi SM,Liu H,Peltonen K,Kucerova A,Schneider DA,Laiho M

更新日期：2018-04-10 00:00:00

abstract：:Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate and are thus essential for glutamatergic neurotransmission. However, VGLUTs were originally discovered as members of a transporter subfamily specific for inorganic phosphate (Pi). It is still unclear how VGLUTs accommodate glutamate transp...

journal_title：Cell reports

authors： Preobraschenski J,Cheret C,Ganzella M,Zander JF,Richter K,Schenck S,Jahn R,Ahnert-Hilger G

更新日期：2018-04-10 00:00:00

abstract：:This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recurrent chromosomal copy-number alterations (CNAs), DNA mutations...

journal_title：Cell reports

authors： Campbell JD,Yau C,Bowlby R,Liu Y,Brennan K,Fan H,Taylor AM,Wang C,Walter V,Akbani R,Byers LA,Creighton CJ,Coarfa C,Shih J,Cherniack AD,Gevaert O,Prunello M,Shen H,Anur P,Chen J,Cheng H,Hayes DN,Bullman S,Ped

更新日期：2018-04-03 00:00:00

abstract：:Learning critically depends on the ability to rapidly form and store non-overlapping representations of the external world. In line with their postulated role in episodic memory, hippocampal place cells can undergo a rapid reorganization of their firing fields upon contextual manipulations. To explore the mechanisms u...

journal_title：Cell reports

authors： Diamantaki M,Coletta S,Nasr K,Zeraati R,Laturnus S,Berens P,Preston-Ferrer P,Burgalossi A

更新日期：2018-04-03 00:00:00